Integrin beta 4 anticorps (CF®647)

N° du produit ABIN6157641

Cet anticorps Souris Monoclonal détecte spécifiquement Integrin beta 4 dans FACS, IF et BR. Il présente une réactivité envers Humain.

Aperçu rapide pour Integrin beta 4 anticorps (CF®647) (ABIN6157641)

Antigène: Integrin beta 4 (ITGB4)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Integrin beta 4 est conjugé à/à la CF®647

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Blocking Reagent (BR)

Clone: UM-A9

Détail du produit anti-Integrin beta 4 anticorps (CF®647)

Fonction: Mouse Monoclonal anti-CD104 (UM-A9), CF647 Conjugate

Attributs du produit: This antibody recognizes a protein of 205 kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Human squamous cell carcinoma (UM-SCC1)

Isotype: IgG2a kappa

Information d'application

Indications d'application: Biological blockade partially blocks laminin binding

• Immunofluorescence 0.5-1 μg/mL
• Flow Cytometry 0.5-1 μg/million cells/0.1 mL
• Optimal dilution for a specific application should be determined by user

Commentaires:

A431 cells, squamous cell carcinoma, colon or placenta

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS/0.1 % BSA/0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Détails sur Integrin beta 4

Antigène: Integrin beta 4 (ITGB4)

Autre désignation: CD104

Sujet: GP150, Integrin beta-4, ITGB4

Poids moléculaire: 205 kDa

ID gène: 3691, 632226

UniProt: P16144

Pathways: Integrin Complex